AWS Lambda is the go-to service when moving from always-on EC2 to serverless, event-driven compute. It’s simple, cost-effective, and scales automatically.

But Lambda isn’t limitless. As workloads grow more complex, compute-heavy, or long-running, Lambda’s hard limits force teams to look elsewhere. The key is to maintain scale-to-zero economics while choosing the right service for the workload.

Use Case: Genomics Data Processing Pipeline

A biotech company started with Lambda to handle DNA sequencing jobs

  • Ran only a few times per day.

  • Each job lasted under 10 minutes.

  • Required modest memory (~2 GB).

As research grew

  • Some jobs stretched to hours.

  • Memory demand ballooned to 30 GB.

  • GPU acceleration became critical for ML models.

  • Specialized libraries exceeded Lambda’s packaging and storage limits.

Solution

  • Preprocessing jobs remained on Lambda.

  • GPU-heavy analysis moved to AWS Batch with Spot Instances.

  • Containerized intermediate steps ran on Fargate one-off tasks.

This hybrid approach maintained cost efficiency without reverting to idle EC2 instances.

Lambda’s Hard Limits

Constraint

Limit

Impact

Runtime

15 minutes

Longer jobs fail.

Memory

10 GB (~6 vCPUs)

Heavy jobs won’t fit.

Ephemeral storage

10 GB max

Limits data-heavy workloads.

GPU support

None

Blocks ML, rendering, HPC.

Bursty workloads

Cold starts + concurrency quotas

May affect performance.

Cost-Optimized Alternatives

Service

Best For

Why It Works

Lambda

Short, light jobs (<15 min, ≤10 GB mem)

Cheapest, simplest serverless option.

Fargate one-off task

>15 min jobs, higher CPU/memory, custom runtimes

Serverless containers, flexible resources.

AWS Batch

Long jobs, GPUs, HPC, pipelines

Managed job scheduler, EC2 Spot savings.

EC2 ASG (min=0)

Legacy or VM-based apps

Scale-to-zero pattern, full OS control.

Decision Cheat Sheet

Requirement

Best Choice

Why

<15 min, ≤10 GB, no GPU

Lambda

Easiest & lowest cost.

>15 min, high memory/CPU

Fargate one-off task

Serverless containers.

GPU, HPC, large job arrays

AWS Batch

Specialized compute with Spot savings.

Legacy VM workloads

EC2 ASG min=0

Full control + cost savings.

AWS Exam Insights

  • “Runs a few times a day” → Event-driven → Lambda.

  • “Needs more memory/runtime than Lambda supports” → Fargate or Batch.

  • “GPU” → AWS Batch with GPU instances (Spot if possible).

  • “Legacy app” → EC2 with scale-to-zero pattern.

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